Saturday, June 29, 2013

Most Influential Ad Execs On Twitter - Business Insider

When we asked our friends at PeekAnalytics to tell us who the most influential ad execs on Twitter are, we expected to get back a list of the usual suspects. You know, the most famous CEOs at the biggest agencies, plus Seth Godin, Lee Clow's Beard, and perhaps KBS+'s Lori Senecal, who once bought promoted tweets for herself.

In fact, none of the huge names of advertising are influential on Twitter, according to PeekAnalytics. The company ranked our Twitterers by "social pull" as opposed to mere total followers. Social pull is a "metric which takes into account not only the quantity of each audience's connections across 60 social networking sites, but also how active and connected, and therefore influential, those connections are."

One of the names on our list has an amazing 313,000 followers. Most have more than 10,000, with many in the mid five figures.

We learned that to be successful on Twitter as an ad exec, you have to be positive and upbeat. No Debbie Downers here.

The way to get retweeted is to give advice, and offer a lot of aphorisms about success in business.

The medium also lends itself to specialists like John Sonnhalter. He has nearly 14,000 followers on Twitter but few on Madison Avenue will recognize his name ? he specializes in ads and sales for the construction business.

Source: http://www.businessinsider.com/most-influential-ad-execs-on-twitter-2013-6

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Polymer coatings a key step toward oral delivery of protein-based drugs

June 27, 2013 ? For protein-based drugs such as insulin to be taken orally rather than injected, bioengineers need to find a way to shuttle them safely through the stomach to the small intestine where they can be absorbed and distributed by the bloodstream. Progress has been slow, but in a new study, researchers report an important technological advance: They show that a "bioadhesive" coating significantly increased the intestinal uptake of polymer nanoparticles in rats and that the nanoparticles were delivered to tissues around the body in a way that could potentially be controlled.

"The results of these studies provide strong support for the use of bioadhesive polymers to enhance nano- and microparticle uptake from the small intestine for oral drug delivery," wrote the researchers in the Journal of Controlled Release, led by corresponding author Edith Mathiowitz, professor of medical science at Brown University.

Mathiowitz, who teaches in Brown's Department of Molecular Pharmacology, Physiology, and Biotechnology, has been working for more than a decade to develop bioadhesive coatings that can get nanoparticles to stick to the mucosal lining of the intestine so that they will be taken up into its epithelial cells and transferred into the bloodstream. The idea is that protein-based medicines would be carried in the nanoparticles.

In the new study, which appeared online June 21, Mathiowitz put one of her most promising coatings, a chemical called PBMAD, to the test both on the lab bench and in animal models. Mathiowitz and her colleagues have applied for a patent related to the work, which would be assigned to Brown University.

In prior experiments, Mathiowitz and her group have shown not only that PBMAD has bioadhesive properties, but also that it withstands the acidic environment of the stomach and then dissolves in the higher pH of the small intestine.

Adhere, absorb, arrive

The newly published results focused on the question of how many particles, whether coated with PBMAD or not, would be taken up by the intestine and distributed to tissues. For easier tracking throughout the body, Mathiowitz's team purposely used experimental and control particles made of materials that the body would not break down. Because they were "non-erodible" the particles did not carry any medicine.

The researchers used particles about 500 nanometers in diameter made of two different materials: polystyrene, which adheres pretty well to the intestine's mucosal lining, and another plastic called PMMA, that does not. They coated some of the PMMA particles in PBMAD, to see if the bioadhesive coating could get PMMA particles to stick more reliably to the intestine and then get absorbed.

First the team, including authors Joshua Reineke of Wayne State University and Daniel Cho of Brown, performed basic benchtop tests to see how well each kind of particles adhered. The PBMAD-coated particles proved to have the strongest stickiness to intestinal tissue, binding more than twice as strongly as the uncoated PMMA particles and about 1.5 times as strongly as the polystyrene particles.

The main experiment, however, involved injecting doses of the different particles into the intestines of rats to see whether they would be absorbed and where those that were taken up could be found five hours later. Some rats got a dose of the polystyrene particles, some got the uncoated PMMA and some got the PBMAD-coated PMMA particles.

Measurements showed that the rats absorbed 66.9 percent of the PBMAD-coated particles, 45.8 percent of the polystyrene particles and only 1.9 percent of the uncoated PMMA partcles.

Meanwhile, the different particles had very different distribution profiles around the body. More than 80 percent of the polystyrene particles that were absorbed went to the liver and another 10 percent went to the kidneys. The PMMA particles, coated or not, found their way to a much wider variety of tissues, although in different distributions. For example, the PBMAD-coated particles were much more likely to reach the heart, while the uncoated ones were much more likely to reach the brain.

Pharmaceutical potential

The apparent fact that the differing surface properties of the similarly sized particles had such distinct distributions in the rats' tissues after the same five-hour period suggests that scientists could learn to tune particles to reach specific parts of the body, essentially targeting doses of medicines taken orally, Mathiowitz said.

"The distribution in the body can be somehow controlled with the type of polymer that you use," she said.

For now, she and her group have been working hard to determine the biophysics of how the PBMAD-coated particles are taken up by the intestines. More work also needs to be done, for instance to demonstrate actual delivery of protein-based medicines in sufficient quantity to tissues where they are needed.

But Mathiowitz said the new results give her considerable confidence.

"What this means now is that if I coat bioerodible nanoparticles correctly, I can enhance their uptake," she said. "Bioerodible nanoparticles are what we would ultimately like to use to deliver proteins. The question we address in this paper is how much can we deliver. The numbers we saw make the goal more feasible."

Another frontier for the delivery of nanoparticles is devising a safe method to make nanoparticles, Mathiowitz said, but, "we have already developed safe and reproducible methods to encapsulate proteins in tiny nanoparticles without compromising their biological activity."

In addition to Reineke, Cho, and Mathiowitz, other authors on the paper are Yu-Ting Liu Dingle, Stacia Furtado, Bryan Laulicht, Danya Lavin, and Peter M. Cheifetz, all of Brown University during the research.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_technology/~3/XPzxGGf6RI8/130627125317.htm

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Sunday, June 16, 2013

China's Space Docking Is Step Toward Ambitious Future in Space

Three Chinese astronauts are currently visiting China's Tiangong 1 space lab in orbit on the country's fifth manned mission to space. The flight, which has been going smoothly so far, officials say, is a step toward the country's long-term plan to build and operate a larger space station in the future.

The three-astronaut team of the Shenzhou 10 mission ? Nie Haisheng, Zhang Xiaoguang and Wang Yaping ? closely monitored their spacecraft's automatic docking process with Tiangong 1 on Thursday (June 13), reporting back to ground control the status of the auto-navigation control mode link-up.

During their 15-day space trek ? which is set to become the longest duration mission to date in China's human spaceflight program ? the trio of "taikonauts" will change and repair some of the equipment and facilities within the live-in space module, as well as carry out a manual docking with Tiangong 1 prior to the crew's return to Earth. [The Shenzhou 10 Mission in Photos]

While onboard Tiangong 1, the Chinese astronauts are slated to conduct space medicine experiments, technology experiments, as well as broadcast a lecture to Earth-bound primary and middle-school students about the physics of microgravity.

"We are all students in facing the vast universe," Wang said prior to the liftoff, according to Agence-France Presse. "We are looking forward to joining our young friends to learn and explore the mystical and beautiful universe."

Auto-docking

The docking between the Shenzhou 10 and Tiangong 1 vehicles was the fifth docking between Shenzhou-type spacecraft and the target module. Previous dockings included two automated operations by the unpiloted Shenzhou 8 in 2011 and both an automated and manual docking by the piloted Shenzhou 9 mission last year.

"The docking appears to have occurred exactly on time," said Bob Christy of the Zarya.info website, and was within one minute of that website's prelaunch estimate based on the earlier Shenzhou 8 and Shenzhou 9 missions.

Christy noted that a diagram on a video screen in the Beijing Aerospace Command and Control Center showed Tiangong with its docking unit pointing backward. It also showed that Shenzhou 10 used an independent elliptical orbit that caused it to approach Tiangong 1 from below before falling in behind it to dock.

For the two previous missions, Shenzhou first matched its orbit with Tiangong and then closed the gap slowly in order to dock, Christy told SPACE.com.

Shenzhou 10 launched June 11 atop a Chinese Long March 2F rocket from the Jiuquan Satellite Launch Center in the Gobi desert.

Tiangong 2

The Tiangong 1 target module has been circling Earth since September 2011.

According to Chinese media outlets, that module is to remain in service for another three months. "It has to move up or it will re-enter naturally in a small number of weeks," Christy said.

According to news reports, Tiangong 1 is to be de-orbited, or destroyed by letting it fall through Earth's atmosphere, said Dean Cheng, a research fellow on Chinese political and security affairs at the Heritage Foundation in Washington, D.C.

"Why? Even if it was only an initial prototype," Cheng said, "what is wrong with the vehicle ? or what has been exhausted ? that they feel the need to de-orbit, rather than use it as a stepping stone?"

Some China space watchers have predicted the development of a Tiangong 2 module, an improved design that would feature an orbital fueling capability, gassed up by a cargo vehicle. That space lab module may be outfitted by a robotic arm system, appraised in space and later adapted to assist in fabricating a larger space station in the 2020 time period.

End of the beginning

Cheng told SPACE.com that the Shenzhou 10 mission likely marks "the end of the beginning," a crowning achievement for the Shenzhou program, marking a decade of piloted Chinese missions.

"This is not the end, however. Like [the U.S.] Mercury or Gemini programs ? really, the two rolled together ? this phase has been an opportunity to test technologies, provide training opportunities, and garner invaluable data for the main goal ? Project 863-205 ? a Chinese space station," Cheng said.

However, less clear, Cheng said, is what missions the Chinese will undertake between now and when they orbit the space station.

"I suspect the long pole in the tent is the Long March 5 vehicle, which Western press reports suggest is running into difficulties," Cheng said. "If they cannot get that to operational capability, can they meet the 2020 deadline?"

Long March leftovers

One interesting side story to the launch of Shenzhou 10 were reports by Chinese news outlets regarding Long March 2F leftovers that fell to the ground.

Fragments of the booster's nose cone shroud and black boxes were found near the city of Yulin in Shaanxi Province, Northern China. Segments of the fairing (the part of the rocket that covers the payload) dropped into a precalculated area in which ground search teams were at the ready to pick up the components.

Pieces of Shenzhou 10's escape tower also were recovered in China's Inner Mongolia.

Leonard David has been reporting on the space industry for more than five decades. He is former director of research for the National Commission on Space and is co-author of Buzz Aldrin's new book, "Mission to Mars ? My Vision for Space Exploration," published by National Geographic. Follow us @Spacedotcom, Facebook and Google+. Original article on SPACE.com.

Copyright 2013 SPACE.com, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Source: http://news.yahoo.com/chinas-space-docking-step-toward-ambitious-future-space-165754137.html

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Saturday, June 15, 2013

Google launches Internet-beaming balloons

(AP) ? Wrinkled and skinny at first, the translucent, jellyfish-shaped balloons that Google released this week from a frozen field in the heart of New Zealand's South Island hardened into shiny pumpkins as they rose into the blue winter skies above Lake Tekapo, passing the first big test of a lofty goal to get the entire planet online.

It was the culmination of 18 months' work on what Google calls Project Loon, in recognition of how wacky the idea may sound. Developed in the secretive X lab that came up with a driverless car and web-surfing eyeglasses, the flimsy helium-filled inflatables beam the Internet down to earth as they sail past on the wind.

Still in their experimental stage, the balloons were the first of thousands that Google's leaders eventually hope to launch 20 kilometers (12 miles) into the stratosphere in order to bridge the gaping digital divide between the world's 4.8 billion unwired people and their 2.2 billion plugged-in counterparts.

If successful, the technology might allow countries to leapfrog the expense of laying fiber cable, dramatically increasing Internet usage in places such as Africa and Southeast Asia.

"It's a huge moonshot. A really big goal to go after," said project leader Mike Cassidy. "The power of the Internet is probably one of the most transformative technologies of our time."

The first person to get Google Balloon Internet access this week was Charles Nimmo, a farmer and entrepreneur in the small town of Leeston. He found the experience a little bemusing after he was one of 50 locals who signed up to be a tester for a project that was so secret, no one would explain to them what was happening. Technicians came to the volunteers' homes and attached to the outside walls bright red receivers the size of basketballs and resembling giant Google map pins.

Nimmo got the Internet for about 15 minutes before the balloon transmitting it sailed on past. His first stop on the Web was to check out the weather because he wanted to find out if it was an optimal time for "crutching" his sheep, a term he explained to the technicians refers to removing the wool around sheep's rear ends.

Nimmo is among the many rural folk, even in developed countries, that can't get broadband access. After ditching his dial-up four years ago in favor of satellite Internet service, he's found himself stuck with bills that sometimes exceed $1,000 in a single month.

"It's been weird," Nimmo said of the Google Balloon Internet experience. "But it's been exciting to be part of something new."

While the concept is new, people have used balloons for communication, transportation and entertainment for centuries. In recent years, the military and aeronautical researchers have used tethered balloons to beam Internet signals back to bases on earth.

Google's balloons fly free and out of eyesight, scavenging power from card table-sized solar panels that dangle below and gather enough charge in four hours to power them for a day as the balloons sail around the globe on the prevailing winds. Far below, ground stations with Internet capabilities about 100 kilometers (60 miles) apart bounce signals up to the balloons.

The signals would hop forward, from one balloon to the next, along a backbone of up to five balloons.

Each balloon would provide Internet service for an area twice the size of New York City, about 1,250 square kilometers (780 square miles), and terrain is not a challenge. They could stream Internet into Afghanistan's steep and winding Khyber Pass or Yaounde, the capital of Cameroon, a country where the World Bank estimates four out of every 100 people are online.

There are plenty of catches, including a requirement that anyone using Google Balloon Internet would need a receiver plugged into their computer in order to receive the signal. Google is not talking costs at this point, although they're striving to make both the balloons and receivers as inexpensive as possible, dramatically less than laying cables.

The signals travel in the unlicensed spectrum, which means Google doesn't have to go through the onerous regulatory processes required for Internet providers using wireless communications networks or satellites. In New Zealand, the company worked with the Civil Aviation Authority on the trial. Google chose the country in part because of its remoteness. Cassidy said in the next phase of the trial they hope to get up to 300 balloons forming a ring on the 40th parallel south from New Zealand through Australia, Chile, Uruguay, Paraguay and Argentina.

Christchurch was a symbolic launch site because some residents were cut off from online information for weeks following a 2011 earthquake that killed 185 people. Google believes balloon access could help places suffering natural disasters get quickly back online. Tania Gilchrist, a resident who signed up for the Google trial, feels lucky she lost her power for only about 10 hours on the day of the quake.

"After the initial upheaval, the Internet really came into play," she said. "It was how people coordinated relief efforts and let people know how to get in touch with agencies. It was really, really effective and it wasn't necessarily driven by the authorities."

At Google's mission control in Christchurch this week, a team of jet lagged engineers working at eight large laptops used wind data from the National Oceanic and Atmospheric Administration to maneuver the balloons over snowy peaks, identifying the wind layer with the desired speed and direction and then adjusting balloons' altitudes so they floated in that layer.

"It's a very fundamentally democratic thing that what links everyone together is the sky and the winds," said Richard DeVaul, an MIT-trained scientist who founded Project Loon and helped develop Google Glass, hidden camera-equipped eyeglasses with a tiny computer display that responds to voice commands.

DeVaul initially thought their biggest challenge would be establishing the radio links from earth to sky, but in the end, one of the most complex parts was hand building strong, light, durable balloons that could handle temperature and pressure swings in the stratosphere.

Google engineers studied balloon science from NASA, the Defense Department and the Jet Propulsion Lab to design their own airships made of plastic films similar to grocery bags. Hundreds have been built so far.

He said they wouldn't interfere with aircraft because they fly well below satellites and twice as high as airplanes, and they downplayed concerns about surveillance, emphasizing that they would not carry cameras or any other extraneous equipment.

The balloons would be guided to collection points and replaced periodically. In cases when they failed, a parachute would deploy.

While there had been rumors, until now Google had refused to confirm the project. But there have been hints: In April, Google's executive chairman tweeted "For every person online, there are two who are not. By the end of the decade, everyone on Earth will be connected," prompting a flurry of speculative reports.

And international aid groups have been pushing for more connectivity for more than a decade.

In pilot projects, African farmers solved disease outbreaks after searching the Web, while in Bangladesh "online schools" bring teachers from Dhaka to children in remote classrooms through large screens and video conferencing.

Many experts said the project has the potential to fast-forward developing nations into the digital age, possibly impacting far more people than the Google X lab's first two projects: The glasses and a fleet of self-driving cars that have already logged hundreds of thousands of accident-free miles.

"Whole segments of the population would reap enormous benefits, from social inclusion to educational and economic opportunities," said DePauw University media studies professor Kevin Howley.

Temple University communications professor Patrick Murphy warned of mixed consequences, pointing to China and Brazil where Internet service increased democratic principles, prompting social movements and uprisings, but also a surge in consumerism that has resulted in environmental and health problems.

"The nutritional and medical information, farming techniques, democratic principles those are the wonderful parts of it," he said. "But you also have everyone wanting to drive a car, eat a steak, drink a Coke."

As the world's largest advertising network, Google itself stands to expand its own empire by bringing Internet to the masses: More users means more potential Google searchers, which in turn give the company more chances to display their lucrative ads.

Richard Bennett, a fellow with the nonprofit Information Technology and Innovation Foundation, was skeptical, noting that cell phones are being used far more in developing countries.

"I'm really glad that Google is doing this kind of speculative research," he said. "But it remains to be seen how practical any of these things are."

Ken Murdoch, a chief information officer for the nonprofit Save the Children, said the service would be "a tremendous key enabler" during natural disasters and humanitarian crises, when infrastructure can be nonexistent or paralyzed.

"The potential of a system that can restore connectivity within hours of a crisis hitting is tremendously exciting," agreed Imogen Wall at the United Nations Office for the Coordination of Humanitarian Affairs, although she warned that the service must be robust. "If the service fails in a crisis, then lives are lost."

In Christchurch this week, the balloons were invisible in the sky except for an occasional glint, but people could see them if they happened to be in the remote countryside where they were launched or through binoculars, if they knew where to look.

Before heading to New Zealand, Google spent a few months secretly launching between two and five flights a week in California's central valley, prompting what Google's scientists said were a handful of unusual reports on local media.

"We were chasing balloons around from trucks on the ground," said DeVaul, "and people were calling in reports about UFOs."

___

Mendoza reported from Mountain View, Calif. Follow Martha Mendoza at http://twitter.com/mendozamartha.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/495d344a0d10421e9baa8ee77029cfbd/Article_2013-06-15-Google%20Internet%20Balloon/id-8688b2e5ecaa4a56bddb704f1a32299d

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Friday, June 14, 2013

Google Adds 1,000 New Locations From Asia, Europe, Latin America, the U.S. and Canada To Street View

singapore_street_viewGoogle today launched a large update to Google Maps that adds more than 1,000 new locations from around the world to the service’s Street View feature. These include numerous locations that can’t be reached by car, including the cathedral of Seville, the canals of Copenhagen and the Singapore Zoo. Overall, it seems, this update focuses on locations from Asia, Europe, Latin America, the U.S. and Canada. Google, of course, has long been expanding Street View’s reach beyond cities and rural streets, thanks to its backpack-like Trekker, tricycles and, most recently, its underwater Street View scooter. Today’s update, Google says, includes numerous historical landmarks and sports stadiums, but it’s also adding some ski slopes in Chile and other relatively unusual locations to its lineup. Today’s large rollout hints at the fact that Google is speeding up its Street View imaging efforts. Until now, it would often announce some of these projects individually. Now, however, it’s adding a huge amount of locations from around the world in one launch, even though quite a few of them are probably a first for the Street View team. All of this imagery, of course, is available on the web, as well as on Google Maps for Android and iPhone.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/ouxF1irUbVg/

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To Stop Being the Party of Stupid You Must Stop Being Stupid (Atlantic Politics Channel)

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